Abstract

This paper presents a novel computer-aided modeling of 3D tissue scaffolds with a controlled internal architecture. The complex internal architecture of scaffolds is biomimetically modeled with controlled micro-architecture to satisfy dissimilar and sometimes alien functional requirements. A functionally gradient porosity function is used to vary the porosity of the designed scaffolds spatially to mimic the functionality of tissues or organs. The 3-dimensional porous structures of the scaffold are geometrically division into functionally compatible porosity regions with a novel offsetting performance technique described in this paper. After determining the functionally uniform porous regions, an optimized degradation-path planning is presented to generate the variational internal porosity architecture with enhanced command of interconnected channel networks and continuous filament deposition. The presented methods are implemented, and illustrative examples are presented in this paper. Moreover, a sample optimized tool path for each example is fabricated layer-past-layer using a micronozzle biomaterial deposition organisation.

Keywords:

biological organs, biological tissues, medical computing, porosity, porous materials, tissue engineering, tissue engineering, scaffolds, porosity gradient, interconnected porous compages, optimum deposition-path planning

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